Ethereal Weapon

Per level³

• Rammus can pair Reverberation, Darksteel Talons, Shrink Engine, Mystic Punch, and Ethereal Weapon with Muramana, Blade of the Ruined King, and Seraph's Embrace.⁴
• Pair Ethereal Weapon with Nashor's Tooth and Lich Bane; a squishy enemy should be gone with one E.⁵
• Rengar can use a W-spam build with Mystic Punch for healing and shielding, alongside Ethereal Weapon and Firebrand or Holy Fire.⁶
• For Brand, Ethereal Weapon can be paired with Twice Thrice and Infernal Conduit for damage from his passive.⁷
• A full on-hit build with Ethereal Weapon can melt enemies with a single spell on Brand.⁸
• For Karthus, take Heartsteel first, then build tank or AP; Rylai's is recommended, and switch E on.⁹
• Ethereal Weapon, Moonflair Spellblade, Firebrand, and Infernal Conduit work with Ezreal's Q; Moonflair Spellblade or Mystic Punch can support repeated ability use.¹⁰
• Ethereal Weapon and Moonflair Spellblade can let Hecarim spam Q without auto-attacking.¹¹

• Nasus's Q applies on-hit effects twice. Talon can stack and trigger his passive with W, and Gragas's W can be applied by his other abilities.¹²¹³¹⁴
• Gwen's Q can snip seven times with Ethereal Weapon, Fan, and Dusk and Dawn.¹⁵
• Garen's ultimate resets when used with Ethereal Weapon, Mystic Punch, and Purist Caster.¹⁶
• Blitzcrank's R passive refreshes with Ethereal Weapon.¹⁷
• Ethereal Weapon can work with Heartsteel.¹⁸
• Brand's passive can trigger Ethereal Weapon on every tick.¹⁹
• Ethereal Weapon can work with Cassiopeia and Divine Sunderer.²⁰
• Ethereal Weapon can make Ryze stronger.²¹
• Ethereal Weapon with Moonflair Spellblade can make tick-rate abilities such as Nasus's R or Mordekaiser's passive reduce cooldowns repeatedly.²²

• Ethereal Weapon consumes Ambessa's passive charges without refunding her energy.²³

Ethereal Weapon's maximum level increased from 2 to 3 in patch 26.12.²⁴

Earlier formats

• Blitzcrank's E can trigger from his R passive with Ethereal Weapon and Reverberation, allowing repeated knockups as the effects build.²⁵²⁶ 8x2 duos
• Ethereal Weapon with Reverberation can let Blitzcrank keep triggering E from R passive hits; Mystic Punch, Moonflair Spellblade, or ability haste can help apply stacks faster than they fall off.²⁶ 8x2 duos
• Ethereal Weapon makes abilities refill energized faster, including for Runecarver builds.²⁷ 8x2 duos
• Tahm Kench can apply three passive stacks with one Q when Ethereal Weapon is paired with Dusk and Dawn.²⁸²⁹ 8x2 duos
• Ethereal Weapon with Dusk and Dawn can let Kai'Sa's W trigger her plasma stacks on its own.³⁰²⁹ 8x2 duos
• Ethereal Weapon works with Master of Duality, so abilities grant both AD and AP.³¹ 8x2 duos
• Ethereal Weapon applies on-hits with Malzahar's W; Muramana can be a good purchase with this interaction.³² 8x2 duos
• With Ethereal Weapon, Gragas may not need to weave in auto-attacks to reduce the cooldown of E.³³ 8x2 duos
• Viego can use Q and W with Mystic Punch, Ethereal Weapon, and Moonflair Spellblade to reduce cooldowns.³⁴ 8x2 duos
• Ethereal Weapon can break Talon's R stealth.³⁵³⁶ 8x2 duos
• Ethereal Weapon is recommended with Kha'Zix's evolved R and W, paired with Fulmination.³⁷ 8x2 duos

Ethereal Weapon used to apply Gangplank's passive with his abilities, but it no longer did so in the eight-teams-of-two format.³⁸³⁹⁴⁰ 8x2 duos

• Ethereal Weapon can trigger energized effects faster, including for Runecarver builds.²⁷ 8x2 duos
• Ethereal Weapon with Dusk and Dawn can let Kai'Sa's W trigger her plasma stacks on its own.³⁰²⁹ 8x2 duos
• Ethereal Weapon applies on-hits with Malzahar's W.³² 8x2 duos
• Ethereal Weapon could keep applying its effect to Blitzcrank's R passive until he used his ultimate.⁴¹ 8x2 duos
• Ethereal Weapon Blitzcrank with Reverberation was especially effective.⁴² 8x2 duos